ReumaNederland is de grootste financier van wetenschappelijk reumaonderzoek. De onderzoeken zijn in te delen naar onderzoek naar artrose, ontstekingsreuma en jeugdreuma. Op deze pagina vind je een overzicht van alle lopende onderzoeken.

Living on the edge: tight control of WISP1 expression is key for cartilage homeostasis – dr. Arjen Blom (Radboudumc) – meer informatie
When the cascade dries up: disturbed pre-rRNA processing in OA chondrocytes – dr. Tim Welting (MUMC+)
Modification of the Smad3 linker; missing link between inflammation and chondrocyte hypertrophy in osteoarthritis – prof. dr. Peter van der Kraan (RIMLS/Radboudumc)
Interplay of cholesterol and oxidative stress via LOX-1 fuels the flames of synovitis driving joint destruction in osteoarthritis – dr. Peter van Lent (Radboudumc)
The interplay between MGP and VitK in the ethiology of osteoarthritis – dr. Joyce van Meurs (Erasmus MC)
Dissecting cellular function of fibronectin in articular cartilage; the key to alleviate the burden of osteoarthritis – dr. Ingrid Meulenbelt (LUMC)
Gain of function osteoprotegerin; threat or treat? – dr. Ingrid Meulenbelt (LUMC)
Inflammation-induced SOCS3 leads to deleterious chondrocyte behaviour by altering TGF-β signalling, resulting in progressive cartilage damage in osteoarthritis – dr. Esmeralda Blaney Davidson (Radboudumc)
Inhibition of PCSK9 dampens the flames of synovitis and destruction in cholesterol fuelled osteoarthritis – dr. Peter van Lent (Radboudumc) – meer informatie
Injectable hollow microgels for improved cartilage repair – dr. Jeroen Leijten (Universiteit Twente) – meer informatie
Smart leads for (preventing) OA: deciphering the network that regulates chondrocyte cell fate. – dr. Janine Post (Universiteit Twente)
Micro encapsulation of stem cells for injection therapy to treat osteoarthritis – prof. dr. Marcel Karperien (Universiteit Twente)
Dampening intrinsic danger in osteoarthritis: Validation of novel inhibitors for S100A8/S100A9 heterodimerization – dr. Peter van Lent (Radboudumc)
How to kill the alarm in OA? Alarmins S100A8/9 as targets for pain treatment in inflammatory OA – dr. Arjen Blom (Radboudumc)
Pharmacological attenuation of thyroid hormone signalling: an evidence based treatment option for osteoarthritis – dr. Ingrid Meulenbelt (LUMC)
Towards a BMP-7 peptide-based OA treatment – dr. Tim Welting (MUMC+) – meer informatie
“SmartCulture”: Development of a next generation culture tool for the selection and production of mesenchymal stem cells for cartilage repair – dr. Kavitha Sivasubramaniyan (Erasmus MC)
A novel transcription factor-based sorting approach to select the best cells for cartilage repair – dr. Roberto Narcisi (Erasmus MC) – meer informatie
Platelet Rich plasma Injection Management for Ankle osteoarthritis study (PRIMA): A multi-center, stratified, block-randomized, double-blind, placebo-controlled trial – dr. Hans Tol (AMC)
Objective Assessment of Functional Knee Joint Stability in Patients with Knee Osteoarthritis – prof. dr. Jaap Harlaar (VUmc) – meer informatie
Diagnostic criteria for early osteoarthritis of hip and knee – prof. dr. Sita Bierma-Zeinstra (Erasmus MC)
DART II Does surgical open reduction and internal fixation prevent the development of posttraumatic osteoarthritis in elderly with dislocated intra-articular distal radius fractures? – dr. Gerald Kraan (Reinier de Graaf Groep)
Shaping adaptive immune responses in arthritis: the importance of innate immune cell-derived extracellular vesicles – prof. dr. Esther de Jong (AMC) – meer informatie
Study the immunomodulatory effect of lymph node stromal cells in rheumatic disease – prof. dr. Reina Mebius (VUmc)
Men with arthritis and a wish to conceive: a neglected patient group – dr. Radboud Dolhain (Erasmus MC) – meer informatie
The contribution of non-canonical NF-kB signalling in endothelial cells to pathological bone formation in spondyloarthritis – dr. Sander Tas (AMC/UvA)
Dose REduction Strategy Study of TNF inhibitors in PsA/axSpA patients: DRESS-PS – dr. Alfons den Broeder (Sint Maartenskliniek)
Gender differences in body composition in Axial Spondyloarthritis and relation with treatment response to TNF blockers – prof. dr. Irene van der Horst (VUmc)
A multicentre study of the pre-clinical phase of spondyloarthritis in HLA-B27 positive first degree family members of patients with ankylosing spondylitis: towards disease prevention – prof. dr. Dominique Baeten (AMC/UvA)
Fatigue in spondyloarthritis: from understanding molecular mechanisms to new treatment targets – dr. Mechiel Korte (Universiteit Utrecht) – meer informatie
A multicentre randomized placebo controlled treatment study of leflunomide in polymyalgia rheumatica – dr. Liesbeth Brouwer (UMCG) – meer informatie
The role of endothelial cell-specific noncanonical NF-κB signalling in development/ maintenance of secondary lymphoid organs and tertiary lymphoid organ formation in rheumatoid arthritis – dr. Sander Tas (AMC/UvA)
Extracorporeal shock wave treatment for bone regeneration in ankle arthrodesis – dr. Duncan Meuffels (Erasmus MC) – meer informatie
The Functional Relevance of the Intestinal Microbiome Associated with New-Onset Rheumatoid Arthritis – dr. Shahla Abdollahi (RIMLS/Radboudumc) – meer informatie
Towards understanding the B cell immune response against citrullinated antigens in rheumatoid arthritis – dr. Hans Ulrich Scherer (LUMC)
Mer: the double-edged sword in treatment of rheumatoid arthritis – dr. Fons van de Loo (Radboudumc)
CRP: not only a marker, but also a cause of inflammation in rheumatoid arthritis? – dr. Jeroen den Dunnen (AMC)
HLA and Rheumatoid Arthritis; How do they connect? – prof. dr. René Toes (LUMC)
Anti-CarP antibodies in rheumatoid arthritis, studies on both the antibody and the antigen – dr. Leendert Trouw (LUMC)
The value of ultrasound, alone and in relation with other regularly used biomarkers, for the prediction of rheumatoid arthritis in patients with clinically suspect arthralgia – prof. dr. Annette van der Helm-van Mil (LUMC)
Bright light therapy in rheumatoid arthritis to reduce fatigue and improve disease outcome: a randomized controlled pilot trial – prof. dr. Andrea Evers (Universiteit Leiden) – meer informatie
Prevention of Rheumatoid Arthritis by Rosuvastatin in Seropositive Arthralgia Patients: a Multicenter Double-Blind Randomized Placebo-Controlled Trial – prof. dr. Dirkjan van Schaardenburg (Reade, Amsterdam) – meer informatie
Targeted delivery of Antigen-Drug conjugates to auto-reactive B-cells – prof. dr. René Toes (LUMC) – meer informatie
On the origin of species: dissecting Anti-Modified Protein Antibodies in Rheumatoid Arthritis – prof. dr. René Toes (LUMC) – meer informatie
Rheumatoid factor revisited – dr. Theo Rispens (Sanquin)
Prognostic value of periodontitis and Porphyromonas gingivalis antibodies in rheumatoid arthritis associated autoantibody formation and development – dr. Johanna Westra (UMCG)
Expansion of B-cell receptor clones in blood precedes the onset of rheumatoid arthritis. Can these clones be used to prevent the onset of disease? – dr. Niek de Vries (AMC)
Reducing heterogeneity: Towards a better understanding of RA through advanced cluster analysis – prof. dr. Tom Huizinga (LUMC)
Targeted photoimmunotherapy against synovial fibroblasts to treat inflamed joints in patients with rheumatoid arthritis – dr. M. Buitinga (Radboudumc)
A novel disease model for Giant Cell Arteritis: the antibody-independent role of B cells in the pathogenesis of Giant Cell Arteritis – dr. Maria Sondovici (UMCG)
Aged CD16+ monocytes promote T helper 17-mediated pathology and vascular damage in giant cell arteritis – dr. Liesbeth Brouwer (UMCG)
Antigenic specificities and genetic damage of expanded B cells and B-cell lymphomas in Sjögren’s syndome – dr. Richard Bende (AMC)
REgistry of Sjögren’s syndrome in University Medical Center Groningen: a LongiTudinal study (RESULT).The parotid connection – prof. dr. Hendrika Bootsma (UMCG)
Overexpression of TRIM21/Ro52 by pDCs in Sjögren’s syndrome: An ultra-high affinity Fc receptor to trigger and perpetuate immunopathology – dr. Maarten Hillen (UU)
Targeting pathogenic CCR9 effector T helper cells in primary Sjogren’s syndrome: key orchestrators of lymphoid neogenesis and immunopathology – dr. Joel van Roon (UU)
Defective human salivary gland stem cells: the cause of primary Sjogren’s syndrome? – prof. dr. Frans Kroese (UMCG) – meer informatie
Fatigue or tolerance induction in Sjögren’s syndrome: detrimental or beneficial role for IDO and the tryptophan catabolic pathway? – dr. Marjan Versnel (Erasmus MC)
Unraveling Incomplete Lupus – search for prognostic factors for progression to Systemic Lupus Erythematosus – dr. Karina de Leeuw (UMCG)
Exploiting metabolic reprogramming of plasmacytoid dendritic cells for disease interception for systemic sclerosis – prof. dr. Timothy Radstake (UMC Utrecht)
Targeting deregulated T cell metabolism in juvenile idiopathic arthritis – prof. dr. Paul Coffer (WKZ)
Training immune function in juvenile idiopathic arthritis: A novel pharmacotherapeutic conditioning approach – prof. dr. Andrea Evers (Universiteit Leiden)
RNA-methylation: a novel regulatory process controlling JIA pathogenesis – dr. Jorg van Loosdregt (WKZ) – meer informatie